The perfect combination for cartilage repair

Over 1.2 million articular cartilage injuries occur annually in the U.S. and Europe. Cartilage injuries degenerate into more severe cartilage defects. Patients suffering from knee pain and functional impairment may result in a decrease in quality of life and could eventually require a total knee replacement - if untreated. There are many available technologies for the treatment of articular cartilage defects. However, none of them provide a single-stage ACI using the patient’s own cells.

Why CartiONE?

CartiONE is the first cartilage repair technology that uses the patient’s own chondrocytes to generate hyaline cartilage in one surgery.

Single Surgery

  • Cell mix prepared in one hour within the operating room
  • No cell culturing
  • No second implantation surgery required

Freshly Isolated Chondrocytes

  • No cell culture ensures cells maintain their intrinsic potential to generate hyaline cartilage tissue1

Patient's Cells

  • No risk of disease transfer
  • No risk of rejection

Cell Combination

  • Cellular interaction supports cartilage formation2,3,4
  • No external growth factors required
  • Inhibits hypertrophy (overgrowth of cartilage) procedure5

Wide Selection of Membranes/Carriers

  • Surgeon can select the carrier based on defect type and preference
  • Patient-specific treatment
  • Darling EM, Athanasiou K a. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J. Orthop. Res. 2005;23(2):425-432. doi:10.1016/j.orthres.2004.08.008.
  • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. 2006;98(5):1076-84. doi:10.1002/jcb.20886.
  • Wu L, Sc B, Leijten JCH, et al. Trophic Effects of Mesenchymal Stem Cells Increase Chondrocyte Proliferation and Matrix Formation.  2011;17. doi:10.1089/ten.tea.2010.0517.
  • De Windt TS, Hendriks JAA, Zhao X, et al. Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how? Stem Cells Transl. Med. 2014;3(6):723-733.
  • Cooke ME, Allon AA, Cheng T, et al. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthr. Cartil. 2011:1-9. doi:10.1016/j.joca.2011.07.005.