Patient information

The CartiONE Procedure

None of the currently available techniques have been successful in addressing all key requirements: single procedure, pain relief, autologous-chondrocyte-based, high-quality repair, and easy delivery. CartiONE addresses these requirements.

The CartiONE Procedure

Processing is completed in the operating theatre during a single surgical procedure.

1

Surgeon debrides and measures the size of the cartilage lesion(s).

2

The debrided cartilage and a cartilage biopsy from a non load bearing region of the knee are collected and transferred to the CartiONE technician for processing.

3

Overall amount of cartilage collected is dependent upon the size of the lesion treated.

4

Surgeon collects bone marrow aspirate and transfers it to the technician.

5

The volume of the aspirate is dependent upon the size of the defect treated.

6

The CartiONE technician processes the cartilage tissue to isolate the fresh chondrocytes and  bone marrow aspirate to isolate the mononucleated cells.

7

The cells are mixed to achieve a specific overall cell concentration and ensure the ratio of chondrocytes to mononucleated cells falls within a specified range.

8

After one hour the cell mixture is transferred to the surgeon for implantation on his carrier of choice.

The CartiONE Cell Service requires a trained technician using a mobile cell processing workstation and disposable kits. The CartiONE Cell Service requires approximately one hour from the time the cartilage biopsy is received until the cell mix is delivered to the surgeon.

Why CartiONE?
Click here to see Single Stage ACI Instruct CartiONE 2-Year results AJSM

CartiONE is the first cartilage repair technology that uses patient’s own chondrocytes to generate hyaline cartilage in one surgery.

Single Surgery
  • Cell mix prepared in one hour within the operating room
  • No cell culturing
  • No second implantation surgery required
Freshly Isolated Chondrocytes
  • No cell culture ensures cells maintain their intrinsic potential to generate hyaline cartilage tissue
Patient's Own Cells
  • No risk of disease transfer
  • No risk of rejection
Cell Combination
  • Cellular interaction supports cartilage formation
  • No external growth factors required
  • Inhibits hypertrophy (overgrowth of cartilage) frequently related to the application of (bone-marrow-derived) stem cells
Wide Selection of Membranes/Carriers
  • Surgeon can select the carrier based on defect type and preference
  • Patient-specific treatment